bio Marin Reflection
At Bio Marin they grow, purify, and analyze proteins. They develop medicine for diseases that are considered rare. The are a world leader in providing therapies for patients with rare diseases. Their main goal is to help patients with rare diseases. They also mentioned that they wanted to maximize their shareholders stocks.
While I was at Bio Marin, I learned a lot about proteins. When we toured the Analytical Chemistry part of the facility, I learned that they characterized proteins there. I learned that they use a HPLC to characterize proteins. HPLC is a High Pressure Liquid Chromatography machine. We compared some graphs while touring the analytical chemistry part of Bio Marin.
To purify cells, they used an autoclave machine for sterilization. To determine a protein's charge, scientists use positively charge beads to see which proteins are negatively charged. They also use chromatography columns to purify individual chemical compounds from mixtures of compounds.
To grow proteins in a safe environment, they used bio-reactors. The bioreactors provide the cells with oxygen, heat, and glucose. (Those are the three key components to keeping the cells alive.) I learned that at Bio Marin they use CHO cells, which are Chinese Hamster ovary cells. Lysosomal storage diseases are a group of roughly 50 rare inherited metabolic disorders, which result from defects in lysosomal function. Lysosomes are sacs of enzymes within cells that digest large molecules and pass the fragments on to other parts of the cell for recycling.
I really like seeing all of the equipment that they use at Bio Marin, but I wish we would have learned more about how they grow the CHO cells, and what they do with the fully grown CHO cells.
While I was at Bio Marin, I learned a lot about proteins. When we toured the Analytical Chemistry part of the facility, I learned that they characterized proteins there. I learned that they use a HPLC to characterize proteins. HPLC is a High Pressure Liquid Chromatography machine. We compared some graphs while touring the analytical chemistry part of Bio Marin.
To purify cells, they used an autoclave machine for sterilization. To determine a protein's charge, scientists use positively charge beads to see which proteins are negatively charged. They also use chromatography columns to purify individual chemical compounds from mixtures of compounds.
To grow proteins in a safe environment, they used bio-reactors. The bioreactors provide the cells with oxygen, heat, and glucose. (Those are the three key components to keeping the cells alive.) I learned that at Bio Marin they use CHO cells, which are Chinese Hamster ovary cells. Lysosomal storage diseases are a group of roughly 50 rare inherited metabolic disorders, which result from defects in lysosomal function. Lysosomes are sacs of enzymes within cells that digest large molecules and pass the fragments on to other parts of the cell for recycling.
I really like seeing all of the equipment that they use at Bio Marin, but I wish we would have learned more about how they grow the CHO cells, and what they do with the fully grown CHO cells.